Personal Experiences with Anticoagulants for Coronary Atheroselerosis

embolism, rlheuniiatic heart disease, and periphlleral arteriopathies. During 1942 at various times I talked about the possibility of utilizinog Dicumnarol ini acute coronary thromI)osis with iivo(car(lial infarctioni with Nelson Barker, Wilbur Duryve, Irvinog Wright, and others. Considerable doubt was expressed as to the likely results, but it was agreed that a (linical trial would be worthwhile. About this tile, Claremmee de la Chappelle noted aim incileiic e of 12 per cent thromboembolismi followhicr acute infarction and stated, 'Some day it iay be demiiomlstralted that [mural thrombi] ,-ill be prevented by the use of anl anticoagul it such as heparin or dicoumarin. " In June 1943, after hundreds of patients with throm-